Acadia Pharmaceuticals buys pain drug maker, part of effort to expand on psychosis treatment

first_imgBiotech GET STARTED [email protected] About the Author Reprints Acadia Pharmaceuticals is purchasing a small Texas startup, CerSci, for $52 million in order to acquire a pain drug in the early stages of development, the company said Tuesday.If the drug succeeds, CerSci could receive an additional $887 million in payments for hitting commercial and development milestones. STAT+ is STAT’s premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond. Daily reporting and analysis The most comprehensive industry coverage from a powerhouse team of reporters Subscriber-only newsletters Daily newsletters to brief you on the most important industry news of the day STAT+ Conversations Weekly opportunities to engage with our reporters and leading industry experts in live video conversations Exclusive industry events Premium access to subscriber-only networking events around the country The best reporters in the industry The most trusted and well-connected newsroom in the health care industry And much more Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr. By Matthew Herper Aug. 25, 2020 Reprints Unlock this article by subscribing to STAT+ and enjoy your first 30 days free! GET STARTED Tags biotechnologySTAT+center_img GEORGE FREY/AFP via Getty Images Log In | Learn More Matthew Herper What is it? Senior Writer, Medicine, Editorial Director of Events Matthew covers medical innovation — both its promise and its perils. Acadia Pharmaceuticals buys pain drug maker, part of effort to expand on psychosis treatment What’s included? @matthewherper last_img read more

Deaths in Laois – Sunday, October 20, 2019

first_img Previous articleScoil Chríost Rí basketball teams continue to go from strength to strengthNext articleIn Pictures: Laois Martial Arts successfully compete in 11th competition of the year LaoisToday Reporter Deaths in Laois – Sunday, October 20, 2019 Twitter Facebook GAA By LaoisToday Reporter – 20th October 2019 WhatsApp GAA Facebook Below are the recent deaths in Laois.Ar Dheis De go raibh a anam.Teresa Daly (née Ryan)Westfield, Castletown, Laois / Roscrea, TipperaryTeresa Daly (nee Ryan), Westfield, Castletown, Portlaoise, Co. Laois (eircode R32TK64) and formerly of Longfordwood, Clonakenny, Co. Tipperary, October 18, 2019 (unexpectedly). Deeply regretted and will be sadly missed by her heartbroken husband Donal, daughter Karen, son Gavin, brothers Joe and Sean, step-brothers Patrick and Bernard, son in law John, brothers in law, sisters in law, father in law Peter, nieces, nephews, extended family, relatives, neighbours and friends.Reposing at her home in Westfield this Sunday and Monday evening from 5 o’c with rosary in the house at 8 o’c both evenings. Removal on Tuesday morning (Oct. 22nd.) at 10.30 o’c to St. Edmund’s Church, Castletown (eircode R32KT22), for Funeral Mass at 11 o’c, followed by cremation in Newlands Cross Crematorium, Dublin arriving at 2 o’c.Family flowers only please.Mary Lennon (née Purcell)Mary St, Durrow, LaoisPeacefully in the loving care of the nurses and staff of Brookhaven Nursing Home Ballyragget. Beloved wife of the late Hugh and mother of the late Maureen, Eugene and Emer.Deeply regretted by her loving children Peader, Phil, Carmel, Martina, John, Eamon, Kevin, Niamh and Mark, sister Kathleen, sons in law, daughters in law, grandchildren, great-grandchildren, relatives, neighbours and friends.Reposing in Brookhaven Nursing Home from 2.00pm on Sunday with Rosary at 8.00pm. Removal to Holy Trinity Church, Durrow, on Monday morning for Requiem Mass at 11.00am. Burial immediately afterwards in the adjoining cemetery.Marie MurphyRoses Kileen, Mountmellick, Laois / Rathmore, KerryAnd formerly of East End, Rathmore, Co Kerry. Predeceased by her parents Tim and Nina, and her sister Margaret. Much loved sister of Noreen, Andrew and Don. Deeply regretted by her loving family, brother in law, sister in law, nieces, nephews and the staff and residence of the Muiríosa Foundation, extended family, relatives and friends.Funeral arrangements later.Mick TerrettRathleash, Portarlington, LaoisSuddenly at his residence. Deeply regretted by his loving wife Ann, son Colm, daughter Grainne, grandchildren Dylan, Gwyneth, Corey and Bryan, daughter-in-law Karen, son-in-law Noel, brothers Pat and Joe, brothers-in-law, sisters-in-law, nephews, nieces, relatives and friends.Reposing at Maher’s Chapel of Rest Portarlington on Sunday from 6pm with Rosary at 8pm. Funeral arriving St John’s Church Killenard on Monday for Requiem Mass at 12 noon. Interment afterwards in the adjoining CemeterySr. Claire Marie O’ConnellHoly Family Convent, Naas Road, Newbridge, Kildare / Rathdowney, LaoisO’ CONNELL, Sr. Claire Marie (Newbridge, Co. Kildare and formally of Rathdowney, Co. Laois) – 17th October 2019 (peacefully) at Naas Hospital. Deeply regretted by her sister Sr. Margaret, Holy Family Convent, her brothers Anthony, Bobby and Billy, sisters-in law, extended family and friends, her community and caring staff at the Convent.Reposing on Friday (18th October 2019) in the Holy Family Convent Chapel, Naas Road, Newbridge from 6.30 o’clock. Removal on Saturday morning at 10.45 o’clock to arrive at St. Conleth’s Parish Church, Newbridge for Funeral Mass at 11 o’clock with burial afterwards in St. Conleth’s Cemetery.Julia (Ciss) Horan (née Carroll)1 Church View, Portarlington, Laois/Portlaoise, LaoisFormerly The New Road, Portlaoise. Peacefully at the Regional Hospital Portlaoise. Loving wife of the late Joe. Deeply regretted by her loving daughters Sheila, Elizabeth, Sharon and Josie, brother Peter, 8 grandchildren, 9 great-grandchildren, sons-in-law Philip, Meryvn and John, especially her niece Catherine Lawlor and her husband Pat, her nephew Pad Kearney and his wife Ber, extended family, neighbours and friends.Reposing at Maher’s Chapel of Rest, Portarlington on Friday from 5:30pm with Rosary at 7pm. Removal on Saturday at 10:20am arriving St Michael’s Church, Portarlington for Requiem Mass at 11am. Funeral afterwards to St Michael’s Cemetery, Portarlington.Sister Columbanus (Margaret) KynePresentation Sisters, Mountmellick, Laois/Moycullen, GalwayDied, peacefully, on October 16th, at the Midland Regional Hospital, Portlaoise. Predeceased by her parents Owen and Bridget, brothers Eugene, Michael and Peter. Deeply regretted by her sister Kitty Dowling (Lord Edward Street, Mountmellick), her nieces and nephews, nieces-in-law, nephews-in-law, grandnieces, grandnephews, The Presentation Sisters Mountmellick and the North East Province and all her extended family and friends.Reposing at Presentation Convent, Mountmellick, on Friday 18th of October from 2pm. Prayers at 5.30pm followed by removal to St Joseph’s Parish Church, Mountmellick, arriving at 6pm. Requiem Mass on Saturday at 11am, followed by burial afterwards in St Joseph’s Cemetery, Mountmellick.Kevin CulletonDublin Rd, Portlaoise, LaoisCulleton, ‘Brittas Lodge’, Dublin Rd, Portlaoise and late of Winsdor, Camross and Brittas, Clonaslee, 10th October 2019. Suddenly, in Lanzarote. Kevin, dearly loved husband to Gemma (nee Doran), cherished dad to Aibhe, Kevin, Eve and John, adoring grandfather to Aoife. Deeply regretted by his loving family, Gearoid (fiancé to Aibhe), Keith (partner to Eve), brothers, sisters, brothers in law, sisters in law, nephews, nieces, relatives and friends.On Saturday reposing from 3 pm with rosary at 8pm. Again on Sunday reposing from 3 pm with rosary at 8pm. On Monday, Removal from his residence at 11.30 am to aririve at SS Peter and Paul’s Church for 12 noon Requiem Mass.Interment afterwards in SS Peter and Paul’s Cemetery, Portlaoise. House private on Monday morning please. Family flowers only, donations, if desired, to The Shoebox appeal.Teresa BurkeBorris Rd, Portlaoise, LaoisBurke, Borris Rd., Portaoise and late of Burnwood, Clonad, October 16th 2019. Peacefully surrounded by her loving family. At Kilminchy Lodge Nursing Home. Teresa, daughter of the late Edward and Margaret. Predeceased by her brothers Michael and Patrick and sister Bernadette (USA). Deeply regretted by her brother Eamonn, sisters Patricia and Brid, and Sr Marilyn (USA), sisters-in-law, brother-in-law, aunt, nieces, nephews, relatives and friends.Reposing at Keegans Funeral Home, Portlaoise on Friday evening, from 6.30pm with rosary at 8pm. Removal on Saturday to arrive at St. Fintan’s Church, Raheen for 10.30am Requiem Mass. Interment afterwards in the adjoining cemetery.JP (John Patrick) O’MaraSampsonscourt, Ballinakill, LaoisJP died peacefully at his home surrounded by his loving family. Deeply regretted by his loving wife Margaret, son Brendan, daughters Kay, Denise and Marie, brother Jerry, sisters Helen, Marie, Margaret, Catherine, Anne and Deirdre, aunt Eileen, brothers-in-law, sister-in-law, sons-in-law, daughter-in-law, nieces, nephews, grandchildren, relatives and friends.Reposing at his home (eircode: R32 AY 70) from 3 o’clock on Tuesday with Rosary at 8 o’clock. Removal at 10.30 on Wednesday morning to St. Bridgid’s Church, Ballinakill for Funeral Mass at 11 o’clock. Burial afterwards in St. Brigid’s Cemetery. House private on Wednesday morning please.SEE ALSO – Deaths in Laois – Saturday, October 19, 2019 Home Deaths Deaths in Laois – Sunday, October 20, 2019 Deaths Pinterest Twitter Pinterest Kelly and Farrell lead the way as St Joseph’s claim 2020 U-15 glory Here are all of Wednesday’s Laois GAA results GAA TAGSDeaths in Laois RELATED ARTICLESMORE FROM AUTHOR WhatsApp 2020 U-15 ‘B’ glory for Ballyroan-Abbey following six point win over Killeshinlast_img read more

Laois hurlers to feature twice on live TV as TG4 announce league schedule

first_img Previous articleLaois County Council sell land worth €30,000 for new home with plans for moreNext articleLaois agri-innovators invited to enter national competition with €5,000 up for grabs Steven Millerhttp://www.laoistoday.ieSteven Miller is owner and managing editor of From Laois, Steven studied Journalism in DCU and has 14 years experience in the media, almost 10 of those in an editorial role. Husband of Emily, father of William and Lillian, he’s happiest when he’s telling stories or kicking a point. WhatsApp Electric Picnic RELATED ARTICLESMORE FROM AUTHOR Electric Picnic Laois hurlers to feature twice on live TV as TG4 announce league schedule Twitter Facebook Laois’s other league games will see them at home to Dublin on May 15, at home to Clare on May 23 and away to Antrim in the final round game onThe football action resumes for Laois on Sunday, May 16, away to Clare though there are no details yet as to where that can be watched live.It has been indicated that all games that aren’t on TV will be shown on GAA Go.The Laois footballers also play Cork at home on May 22 and Kildare at home a week later. The top two teams in Laois’s Division 2 South will play in the semi-finals of Division 2 with the bottom two going into the relegation playoffs.The live GAA coverage on May 8-9 will be the first Gaelic games action on TV since last year’s All Ireland football final in December.TG4 will broadcast 25 live games over the coming months with at least four live games every weekend.Saturday, May 8Galway v Westmeath at 2pm on TG4Dublin v Kilkenny at 3.45pm on EirLimerick v Tipperary at 5.30pm on EirSunday, May 9Wexford v Laois at 1.45pm on TG4Cork v Waterford at 3.45pm on TG4Antrim v Clare at 2pm on TG4 appSEE ALSO – Excitement as underage sport resumes but importance of fun and safe environment is highlighted Twitter Home Sport GAA Laois hurlers to feature twice on live TV as TG4 announce league… SportGAAHurling Facebookcenter_img TAGSLaois senior hurlersTG4 WhatsApp Pinterest The Laois hurlers will be shown live on TG4 for their two of their National Hurling League games.The Irish-language station today announced the games they will be broadcasting live over the next couple of months.Laois’s opening game away to Wexford – which will be Cheddar Plunkett’s first game back in charge – will be live on Sunday, May 9, while the TV cameras will also be in Nowlan Park for their Round 4 game against Kilkenny on June 6.All six of the Division 1 games on the opening weekend will be shown live – with three live on TG4, two Saturday games on Eir and the Sunday clash of Antrim v Clare on the TG4 app.The National Hurling League this year consists of five rounds but no knockout stages. With equal-standard groups in Division 1A and 1B, there will be joint winners of the competition unless a final can be facilitated similar to last year when Clare and Limerick in the opening round of the Munster championship also doubled up as the league final. Electric Picnic organisers release statement following confirmation of new festival date Electric Picnic apply to Laois County Council for new date for this year’s festival By Steven Miller – 27th April 2021 Pinterest Council Mary Sweeney elected Cathaoirleach of Portlaoise Municipal District for next 12 monthslast_img read more

NATSEM Federal Budget Analysis: Mid to high income groups may benefit more than people might think

first_imgNATSEM Federal Budget Analysis: Mid to high income groups may benefit more than people might think The National Centre for Social and Economic Modelling (NATSEM) at the University of Canberra has found that mid to high income people are one of the winners from this year’s Federal Budget.NATSEM’s Budget Analysis has found that the extension of the low and middle income tax offset (LMITO) actually benefits higher income families as low-income families often do not earn enough to fully benefit from the tax offset.The report also suggests that the childcare subsidy increase will also benefit mid and high income families given increased childcare use as well as the activity test requirement of the childcare subsidy.“To claim the full benefit from the increased childcare subsidy, families will need to have an income of at least $129,000 a year, as the lower-income families already claim benefit closer to the capped ratio,” said Professor Jinjing Li, who runs NATSEM’s tax modelling.If the childcare price rises due to the increased demand, families with a single child or lower income may even lose out. The removal of the cap of childcare subsidy also favours high-income families.Assuming families use childcare on days when parents are at work, the budget’s impact is likely the largest for the families in the fourth quintile and the lowest for the families in the bottom quintile.“Overall, the impact of the proposed tax transfer policy change in this year’s budget is small compared with the likely impact of the 2024/25 tax cut, which will substantially benefit the higher income groups,” said Professor Li.NATSEM’s report also analyses the impact of the home guarantee scheme where the government lowers the down payment required for the eligible households.The finding from the analysis suggests that there could be up to 6 per cent of potential renters interested in the scheme based on their current savings. However, the percentage is lower at 4.3 per cent for single parents despite a more generous support. Critically for most of them, the potential mortgage repayment would be higher than their current rent.The full analysis can be found here. /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:Australia, Canberra, childcare, Federal, federal budget, Government, Impact, mortgage, Professor, rent, tax, university, University of Canberralast_img read more

Cook with your Boulder campus Staff Council

first_img Related Articles Published: Oct. 19, 2020 As we near the end of October and head toward the winter months, Staff Council would like to share something that you can enjoy in your own home! We have compiled our favorite recipes into an online cookbook, which you’ll find on the Outreach Page on our website. We have the perfect Chili for cool weather and football nights, or how about a Traditional British Sticky Toffee Pudding? We also have vegetarian options like Green Lentils and Rice, and for the meat lovers, Baked Swiss Chicken. Why not cook something wonderful and new this week? And watch Staff Council’s Betty Rasmussen make a delicious Pork Chili Colorado! Do you have a favorite recipe you would like to share? We would be honored to help spread the word about the delicious things CU Boulder staff are making. Please submit your recipes here. We will add all the recipes we receive to our website so other staff on campus can benefit from your delicious foods. We will also choose a few recipes to be our random winners for our raffle prize! Please submit your recipe by Friday, November 20 to be included in the recipe raffle. If you are interested in creating and submitting a video of yourself cooking (preferably sporting some Buff Gear), we would love to get those, too, and will share with staff on campus. Please reach out to [email protected] if you are interested in submitting a cooking video. Happy cooking!Categories:Be engaged.Tags:Outreach2020 Play Virtual Games with Staff Council We take your concerns seriously, of course, but we also look forward to playing games with you! Join us for Yahtzee on October 29 and Jeopardy on November 10. Both games will be via Zoom and require registration prior. Read more Play Bingo with Staff Council! Join Staff Council for a bingo game night! Since we can’t be together in person, we want to bring together people interested in some virtual fun and games! Read more Yahtzee Night with Staff Council October 29 Staff Council will be hosting its first YAHTZEE! Night on Thursday, October 29, at 7:00 p.m., via Zoom. Please register by Wednesday, October 28. You will be contacted with the link to Zoom room, a copy of the score sheet (you can hand write it or print it), rules of the game, and a list of prizes. Read more last_img read more

Second Hand Smoke Just as Dangerous – Ferguson

first_imgSecond Hand Smoke Just as Dangerous – Ferguson Health & WellnessSeptember 11, 2012 RelatedSecond Hand Smoke Just as Dangerous – Ferguson RelatedSecond Hand Smoke Just as Dangerous – Ferguson RelatedSecond Hand Smoke Just as Dangerous – Fergusoncenter_img FacebookTwitterWhatsAppEmail Minister of Health, Hon. Dr. Fenton Ferguson, is again warning of the dangers of second hand smoke, especially to children. The Health Minister, who was addressing a health fair on Saturday (Sept. 8) to mark Caribbean Wellness Day 2012, implored parents to be mindful of smoking around their children as environmental tobacco smoke is just as dangerous as smoking. He pointed out that six million persons are dying every year from cigarette smoking, while 600,000 persons die every year from being in the presence of smokers. “I know you love your children, but many persons smoke the cigarette, blow the smoke in the children’s face and later on they become more susceptible to conditions related to heart disease, high blood pressure and diabetes and so on,” he said, pleading with them to desist from the practice. Scores of persons were treated to free health checks and engaged in activities promoting healthy lifestyle practices during the Caribbean Wellness Day event, which is observed annually on the second Saturday in September. It seeks to showcase national and community level activities to promote healthy living and encourage citizens to develop good health practices. Its observance came out of a landmark summit held in Trinidad and Tobago in September 2007, which saw Caribbean Community (CARICOM) Heads of Government “uniting to stop the epidemic” of non-communicable diseases (NCDs), or chronic conditions such as cardiovascular diseases, cancers, chronic respiratory diseases and diabetes. Dr. Ferguson, in his address, informed that 56 per cent of deaths in Jamaica are as a result of chronic diseases. He encouraged the audience to lead healthier lifestyles and prevent NCDs by exercising, paying special attention to proper nutrition and avoid tobacco smoking and excessive alcohol consumption. Director of Health Promotion and Education in the Ministry, Tekese Foga, told JIS News that Caribbean Wellness Day this year, focused on health promotion in schools, and the event highlighted the work of resource persons, who “support key components of a health-promoting school.” A health promoting school has been defined by the World Health Organization (WHO) as an institution, which strengthens its capacity as a healthy environment for living, learning and working. As such, it becomes a place where all members of the school community work together to provide students with integrated and positive experiences and a structure, which promotes and protects their health. The event featured displays highlighting various initiatives schools have been embarking on to improve the health of students. There was a physical activity station and a chill room where adolescents were provided with information about their health and encouraged to ask questions. An edutainment group also interacted with adolescents regarding healthy lifestyle practices. There was also a nutrition village, which featured the Rural Agricultural Development Authority (RADA) as well as the Ministry of Health’s Nutrition Department, which addressed the area of healthy eating. Booths were also set up by the Jamaica 4-H Clubs, Dispute Resolution Foundation, Ministry of National Security, and the Diabetes Association of Jamaica.  There was also an HIV/STI booth. The day ended with a lively concert. Organised by the Ministry of Health in partnership with the Ministry of Education and the National Health Fund (NHF), the day was observed under the theme: ‘Healthy Schools make Healthy Communities that Build Healthy Countries’. Advertisementslast_img read more

Vodacom drops Neotel deal, citing regulatory complexities

first_img Richard is the editor of Mobile World Live’s money channel and a contributor to the daily news service. He is an experienced technology and business journalist who previously worked as a freelancer for many publications over the last decade including… Read more MTN, Vodafone still standing in Ethiopia contest South African operator Vodacom’s attempt to salvage its proposed acquisition of fixed-line provider Neotel has failed.Vodacom said the deal to buy the majority of Neotel’s assets had lapsed “due to regulatory complexities and certain conditions not being fulfilled”.The two companies “have agreed that the proposed restructured transaction, announced on 8 December 2015, can no longer be progressed,” it added.Following opposition from rivals and concerns expressed by the country’s antitrust regulator, Vodacom said in December it would no longer acquire Neotel’s valuable licences and spectrum, although it would continue to acquire its other assets, customer base and staff.Under the restructured deal, Neotel would offer a roaming agreement to all the country’s mobile operators, including Vodacom as well as rivals, using its radio frequencies.Vodacom’s hope that all parties could accept its restructured offer did not work out. “It is disappointing that we have reached this conclusion despite all our efforts to find a way to deal with the complexities of the restructured transaction,” said Shameel Joosub (pictured), CEO of Vodacom.“Our ambition to increase the rollout of fibre-based broadband services to customers remains. We will continue to look for spectrum opportunities, as well as opportunities to accelerate our fixed line business.” Six suitors to contest South Africa spectrum sale Home Vodacom drops Neotel deal, citing regulatory complexities Richard Handford Previous ArticleInterview: VimpelCom CTONext ArticleInnovation City – Hall 3 AddThis Sharing ButtonsShare to LinkedInLinkedInLinkedInShare to TwitterTwitterTwitterShare to FacebookFacebookFacebookShare to MoreAddThisMore 01 MAR 2016 Torching of MTN, Vodacom towers linked to 5G claims NeotelVodacom Author Related Tags last_img read more

Citrate Death Spiral

first_imgEvolution Citrate Death SpiralMichael BeheJune 17, 2020, 6:05 AM There seemed, however, to be one interesting exception.4 One morning after more than 30,000 generations of bacterial growth, one flask of E. coli (out of 12 separate flasks that Lenski maintained for comparison and replication’s sake) seemed cloudier than the other 11 flasks. That indicated substantially more bacteria than usual had grown in the nutrient broth. After much hard laboratory work, Lenski’s group showed that a region of the prodigious bacterium’s DNA that was close to a gene coding for a citrate transporter (that is, a protein whose job is to bring external, dissolved citrate into the cell; citrate is a common chemical that cells metabolize) had duplicated.5 The duplication mutation placed the control region of a different gene next to that of the citrate transporter. Richard Lenski, by Zachary Blount [CC BY-SA 4.0], from Wikimedia Commons The degraded E. coli was eating its dead. References An Interesting Exception? Origin of Life: Brian Miller Distills a Debate Between Dave Farina and James Tour Email Print Google+ Linkedin Twitter Share It is rarely feasible to examine evolution in action as organisms invade, colonize, and adapt to a new niche in nature, especially with independently evolving replicates and control populations. In this study, we investigated how E. coli variants with the new ability to grow aerobically on citrate adapted to a novel, citrate-only resource environment in the laboratory. Let me emphasize: the only result from the decades-long, 50,000-plus generation E. coli evolution experiment that even seemed at first blush like it had a bit of potential to yield a novel pathway in the bacterium has resulted instead in spectacular devolution. As Lenski and co-authors wrote in Science in 2019 in their dismissive review of Darwin Devolves(which focused strongly on the clear degradation occurring over the course of the LTEE):7 Congratulations to Science Magazine for an Honest Portrayal of Darwin’s Descent of Man Here’s why that helped. The citrate-transporter gene’s natural regulator causes the gene to be turned off whenever oxygen is around, as it was under the normal laboratory growth conditions at MSU. The second regulator, however, allows the gene it controls to be turned on in the presence of oxygen. The mutation that placed a copy of the regulator of the second gene next to the citrate gene then allowed the citrate gene to be turned on in the presence of oxygen, too. Since for technical purposes there was a lot of dissolved citrate in the nutrient broth, the mutant E. coli could import and metabolize (“eat”) the citrate, which was unavailable to nonmutants. With all that extra food, the mutant grew like crazy, quickly surpassing nonmutants. Requesting a (Partial) Retraction from Darrel Falk and BioLogos Recommended Exactly. That means the LTEE gives us our clearest insight into the general effects of Darwin’s mechanism, which continues to operate no matter what other processes may also be occurring (I’m looking at you, Extended Evolutionary Synthesis), no matter whether an organism is in a lab or in the wild, no matter which kind of organism — whether microbe, plant, or animal — is subject to its tender care. So, thanks to the Lenski group, we know that devolution is relentless — it never rests. In good times and bad, if a change in a species could help it adapt more closely to its environment, degradative mutations will arrive most quickly by far to offer their assistance. And, of course, under selective pressure a species has no choice but to accept helpful ones, even if that eventually leads to the species languishing. Thanks in very large part to the fine work done over decades at Michigan State we can now be certain that, like the citrate-eating E. coli, as an explanation for the great features of life Darwin’s theory itself is in a death spiral. Jane Goodall Meets the God Hypothesis The “one new” function was the citrate mutation. I had called it a “side show” in Darwin Devolves precisely because the E. coli of the LTEE were accumulating degradative mutations much faster than any mutations that might with charity be called constructive:3 Interesting as it is, the ambiguous citrate mutation that started the hoopla is a side show. The overwhelmingly important and almost completely unnoticed lesson is that genes are being degraded left and right, both when they directly benefit the bacteria and when they do so indirectly in support of another mutation. The occasional, particularly noticeable modification-of-function or gain-of-FCT mutation can’t turn back the tide of damaging and loss-of-FCT ones. A Sick Puppycenter_img Email Print Google+ Linkedin Twitter Share There are indeed many examples of loss-of-function mutations that are advantageous, but Behe is selective in his examples. He dedicates the better part of chapter 7 to discussing a 65,000-generation Escherichia coli experiment, emphasizing the many mutations that arose that degraded function — an expected mode of adaptation to a simple laboratory environment, by the way — while dismissing improved functions and deriding one new one as a “sideshow”. (Full disclosure: The findings in question were published by co-author Richard Lenski.) The novel result was widely reported, and the conjecture was floated that perhaps the mutant was on its way to forming a new species.6 As I wrote in Darwin Devolves, however, other, much more ominous, genetic results should have tempered any optimism. For example, the citrate mutant had accumulated many of the same beneficial-but-degradative mutations that had previously spread through the population — the new mutation did not, could not, restore them. And later work showed that several more broken genes had been selected in the mutant, apparently to help it metabolize citrate more efficiently.3 A Great Strength TagsbacteriacitrateDarwin DevolvesDarwinian mechanismdevolutionE. colieLifeevolutionfatty acidsgenesgenetic informationLenski labLong Term Evolution ExperimentmetabolismMichigan State UniversitymutationsoxygenRichard Lenski,Trending “A Summary of the Evidence for Intelligent Design”: The Study Guide Michael J. BeheSenior Fellow, Center for Science and CultureMichael J. Behe is Professor of Biological Sciences at Lehigh University in Pennsylvania and a Senior Fellow at Discovery Institute’s Center for Science and Culture. He received his Ph.D. in Biochemistry from the University of Pennsylvania in 1978. Behe’s current research involves delineation of design and natural selection in protein structures. In his career he has authored over 40 technical papers and three books, Darwin Devolves: The New Science About DNA that Challenges Evolution, Darwin’s Black Box: The Biochemical Challenge to Evolution, and The Edge of Evolution: The Search for the Limits of Darwinism, which argue that living system at the molecular level are best explained as being the result of deliberate intelligent design.Follow MikeProfileWebsite Share Photo: Richard Lenski, by Zachary Blount [CC BY-SA 4.0], from Wikimedia Commons. In their new paper the Lenski group rightfully points out the great strength of its experimental evolutionary system.1 Lessons to Draw The more molecular evolutionary work that rolls in, the more the above conclusion becomes a mere truism. The new paper now reports on 2,500 generations of further evolution of the citrate mutant, in nutrient media that contains either citrate alone or citrate plus glucose (as for earlier generations). As always with the Lenski lab, the research is well and thoroughly done. But the resulting E. coli is one sick puppy. Inside the paper they report that “The spectrum of mutations identified in evolved clones was dominated by structural variation, including insertions, deletions, and mobile element transpositions.” All of those are exceedingly likely to break or degrade genes. Dozens more genes were lost. The citrate mutant tossed genetic information with mindless abandon for short term advantage. Michigan State University biologist Richard Lenski and collaborators have just published a terrific new paper in the journal eLife.1 Anyone who wants to see a crystal-clear example of the inherent, unavoidable, fatal difficulties that the Darwinian mechanism itself poses for unguided evolution should read it closely. Blount, Z., et al. (2020). “Genomic and phenotypic evolution of Escherichia coli in a novel citrate-only resource environment.” eLife 9: e55414.Lenski, R. E. (2017). “Convergence and Divergence in a Long-Term Experiment with Bacteria.” The American Naturalist 190: S57-S68.Behe, M. J. (2019). Darwin devolves: the new science about DNA that challenges evolution. New York, NY, HarperOne, Ch. 7.Blount, Z. D., C. Z. Borland and R. E. Lenski (2008). “Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli.” Proc. Natl. Acad. Sci. USA 105: 7899-7906.Blount, Z. D., et al. (2012). “Genomic analysis of a key innovation in an experimental Escherichia coli population.” Nature 489: 513-518.Pennisi, E. (2013). “The man who bottled evolution.” Science 342: 790-793.Lents, N. H., S. J. Swamidass and R. E. Lenski (2019). “The end of evolution?” Science 363: 590-590. In a particularly telling result, the authors “serendipitously discovered evidence of substantial cell death in cultures of a Cit+ clone sampled from … the LTEE at 50,000 generations.” In other words, those initial random “beneficial” citrate mutations that had been seized on by natural selection tens of thousands of generations earlier had led to a death spiral. The death rate of the ancestor of the LTEE was ~10 percent; after 33,000 generations it was ~30 percent; after 50,000, ~40 percent. For the newer set of experiments, the death rate varied for different strains of cells in different media, but exceeded 50 percent for some cell lines in a citrate-only environment. Indeed, the authors identified a number of mutations — again, almost certainly degradative ones — in genes for fatty acid metabolism that, they write with admirable detachment, “suggest adaptation to scavenging on dead and dying cells.” The paper concerns the further evolution of a widely discussed mutant strain of the bacterium E. coli discovered during the course of Lenski’s Long Term Evolution Experiment (LTEE). The LTEE is his more-than-three-decades-long project in which E. coli was allowed to grow continuously in laboratory flasks simply to observe how it would evolve.2 As I’ve written before, almost all of the beneficial mutations that were discovered to have spread through the populations of bacteria in the LTEE were ones that either blunted pre-existing genes (decreasing their previous biochemical activity) or outright broke them.3 A Physician Describes How Behe Changed His MindLife’s Origin — A “Mystery” Made AccessibleCodes Are Not Products of PhysicsIxnay on the Ambriancay PlosionexhayDesign Triangulation: My Thanksgiving Gift to Alllast_img read more

People / United Cargo reorganises team and appoints KLM’s Jacques Leijssenaar

first_img United Cargo today announced the appointment of Jacques Leijssenaar as vice president, cargo sales EMEIA. In his new role, Mr Leijssenaar reports to United Cargo president Jan Krems, and is responsible for all United Cargo sales activities in the EMEIA region.Mr Leijssenaar comes to United with 18 years’ experience at Air France-KLM Cargo. His most recent position was director Italy and Switzerland, and he has also served as AF/KLM Cargo’s director Benelux and as KLM cargo’s director of sales for South, Central and Eastern Europe. Mr Leijssenaar earned his master’s degree in economics from the University of Amsterdam.United Cargo also described a new alignment in which leaders of the four sales organizations now report directly to Mr Krems. In addition to Mr Leijssenaar, these leaders are:Jim Bellinder, vice president, cargo sales Americas. Mr Bellinder has 28 years’ cargo sales experience with Continental Airlines and United Airlines. He has served as United Cargo’s vice president sales since 2013.Mirco Renfer, vice president, cargo sales Asia Pacific. Mr Renfer joined United Airlines in 2006 and has led United Cargo’s EMEIA region sales since 2008. He will transition from leading EMEIA sales to leading APAC sales for United Cargo.Helen Kristensen, managing director, cargo sales strategic accounts. Ms Kristensen joined United Airlines in 1995 and became cargo sales strategic partner manager in 2007, and has led the accounts since February last year.“We believe this realignment will streamline our decision making and quicken our response to opportunities offered by our customers,” said United Cargo president Jan Krems. “This will enable us to serve as an even more valuable business partner in 2015.”United Cargo further announced the appointment of David O. King as managing director, cargo pricing, revenue management & sales strategy. Mr King first joined Continental Airlines Cargo in 2006 and has led cargo sales Americas for United since 2013. He has also co-led cargo pricing & revenue management on an interim basis since October.United Cargo also reported the retirement of its former Asia Pacific Sales leader, Rick Fall, following a remarkable career of nearly 45 years in the airline industry. “We salute Rick for his dedication and thank him for his countless contributions,” said Mr Krems. “We are certain all his industry colleagues join us in wishing Rick a happy and healthy retirement.” By LoadstarEditorial 16/01/2015last_img read more

SRU accepts penalty for RWC petulance

first_img Scottish Rugby CEO Mark Dodson ‘ AlphaCuteOprah’s New House Cost $90 Million, And This Is What It Looks LikeAlphaCute|SponsoredSponsoredUndoAaron Smith names South African as greatest World Cup scrumhalfSA Rugby MagUndoJapan-based Kiwi player: I hope to never experience this againSA Rugby MagUndo熱門話題對肚腩脂肪感到後悔!試了在萬寧賣的這個後…熱門話題|SponsoredSponsoredUndo SRU accepts penalty for RWC petulance ‘ Buzz TreatmentRemember Grace Jones? Try Not To Smile When You See Her NowBuzz Treatment|SponsoredSponsoredUndo 熱門話題小心會瘦過快…網友推爆:「真的瘦的超誇張!」熱門話題|SponsoredSponsoredUndo ‘ Post by SA Rugby magazine Posted in News, Test Rugby, Top headlines, World Cup Tagged 2019 Rugby World Cup, 2019 World Cup, Rugby World Cup, Scotland, scottish rugby, World Rugby Life Exact BrazilRemember Grace Jones? She Is Almost 73, See Her NowLife Exact Brazil|SponsoredSponsoredUndo World Cup-winning Bok quartet in Eddie Jones’ all-time XVMaverick coach Eddie Jones has named his Test dream team made up of players he has worked with throughout his illustrious career.SA Rugby MagUndoDatemyage.comOver 40 And Single?|SponsoredSponsoredUndoGoGoPeak10 Most Beautiful Cities You Should Visit Once In Your LifetimeGoGoPeak|SponsoredSponsoredUndoBuzzAura16 Cancer Causing Foods You Probably Eat Every DayBuzzAura|SponsoredSponsoredUndoLoans | Search AdsGetting a loan in Hong Kong may be easier than you thinkLoans | Search Ads|SponsoredSponsoredUndoBuzzSuperDetails About Meghan Markle’s Wedding Will Leave You SpeechlessBuzzSuper|SponsoredSponsoredUndo World Rugby has confirmed that the Scottish Rugby Union will not appeal the sanction handed to it for misconduct during the World Cup.Tensions rose during the recently concluded tournament in Japan as Scotland’s pivotal group clash with the hosts was put under threat by typhoon Hagibis.With Scotland needing to win the game to have a chance to progress, Dodson said at a media conference that he did not want his side to be ‘collateral damage’ of the fallout of the typhoon.Two charges of misconduct were brought by World Rugby in line with the Rugby World Cup 2019 Terms of Participation and World Rugby Regulation 20.2 (Misconduct and Code of Conduct).The SRU was found guilty and fined £70,000 as well as ordered to apologise publicly. At the time, the SRU said it is considering all options available to it, including arbitration.However, in a short statement released on Thursday, World Rugby said Scottish Rugby has opted against an appeal and has instead accepted its fate.‘World Rugby can confirm that the Scottish Rugby Union has expressed its regret and has confirmed it will not challenge World Rugby further on this matter. Watch: I wanted to rip Jean’s head off – Jaque FourieSA Rugby MagUndo  0  0 ‘ ‘ ‘The Scottish Rugby Union has agreed to pay a donation of £70,000 to World Rugby and the matter is now closed. There will be no further comment from either party.’Photo: Paul Devlin/SNS Published on November 14, 2019 ‘last_img read more