HKUMed identifies rarely documented pharmacogenetic variants commonly found among Hong Kong Chinese

first_imgHKUMed identifies rarely documented pharmacogenetic variants commonly found among Hong Kong Chinese HKUMed identifies rarely documented pharmacogenetic variants commonly found among Hong Kong Chinese, highlighting the potential for personalised medicine (from left: Mr Mullin Yu Ho-chung, Dr Patrick Chung Ho-yu, Mr William Chui Chun-ming, Professor Paul Tam Kwong-hang, Dr Brian Chung Hon-yin, Professor Godfrey Chan Chi-fung, Professor Lau Yu-lung, Dr Lee So-lun, Dr Yeung Kit-san, Dr Clara Tang Sze-man, Ms Claudia Chung Ching-yan and Mr Marcus Chan Chun-yin).In the first and largest study of its kind among Hong Kong Chinese, a research team at LKS Faculty of Medicine, The University of Hong Kong (HKUMed) has identified 531 rare and predicted deleterious variants in 108 pharmacogenes, among which 96 have never been reported in widely recognised databases. However, these variants were commonly found among Hong Kong Chinese, most of whom (93.6%) having at least one of them. Besides, almost all (99.6%) Hong Kong Chinese residents harboured at least one actionable pharmacogenetic variant, which may impact the effectiveness of drug treatment. This study, which demonstrates the potential of pharmacogenetics in personalised prescription of medicine for reduced risk of adverse reactions and enhanced drug efficacy, has been published in PLOS Genetics. [Link to the publication].About pharmacogeneticsPharmacogenetics is the study of genetic influences on variability of drug response. Genetic variants in enzyme genes determine the enzyme activities in human body, thus leading to variable rate of drug metabolism. When prescribed with the standard dosage, patients with high metabolism may find the drug less effective than expected as the drug is quickly broken down and loses its function. By contrast, drug remains active for longer in patients with slow metabolism. Blood concentration of drug in these patients may reach toxic levels, causing undesired adverse drug reactions. Over two million patients in the United States suffer from adverse drug reactions every year, incurring a considerable medical cost of US$200 billion1.About the studyThe HKUMed research team examined actionable and rarely documented pharmacogenetic variants using two sets of big data. One was the exome sequencing (ES) data of 1,116 Hong Kong Chinese individuals. Covering more than 20,000 genes, the ES data set of the largest Hong Kong Chinese cohort to date characterises a representative spectrum of every variant.Another set of big data was the anonymous drug prescription data in the Clinical Data Analysis and Reporting System database of the Hospital Authority (HA), the backbone of Hong Kong public healthcare system serving 7.5 million people in the city. Combining information extracted from these two sets of big data, this research provides reliable evidence for prescription decisions and medical resource management for the Hong Kong Chinese population.Utilising the largest Hong Kong Chinese pharmacogenetics database to date, the research team identified 531 rare and predicted deleterious variants in 108 pharmacogenes, among which 96 variants have never been reported in any genetic databases. Despite their rarity, 93.6% of the Hong Kong Chinese carried at least one of the 531 rare pharmacogenetic variants.The research team also evaluated 133 pharmacogenetics variants that are known to affect drug responses in patients. According to international clinical guidelines, these 133 pharmacogenetics variants affect the metabolism of 36 drugs. Consistent with other populations, almost all (99.6%) Hong Kong Chinese residents harboured at least one actionable pharmacogenetic variant, with a median of four. Nevertheless, the local spectrum of actionable variants was different compared to those of foreign populations. For example, when azathioprine is prescribed, local clinicians should consider defective NUDT15 alleles which is about 19 times more frequent in Hong Kong Chinese population than in Europeans and Africans. Defective TPMT alleles should be considered in Europeans instead2,3. This implies that the clinical application of pharmacogenetic guidelines should be customised for different ethnic groups.Pharmacogenetics for the peopleCurrent pharmacogenetic testing only investigates the genetic influences when high-risk medications are prescribed, or after adverse drug reactions occur. This means the patients could have been impacted before remedial actions are taken. To address this issue, the HKUMed research team recommends a pre-emptive approach, by which pharmacogenetic testing is conducted to provide actionable recommendations to the choice and dosage of drugs based on the genetic profile of each patient before prescription. This approach will help reduce the risk of adverse drug reactions and enhance drug efficacy.Clinical guideline recommendations associated with pharmacogenetic variants have the potential to be widely adopted in Hong Kong. According to the HA statistics, a total of 1,006,046 Hong Kong Chinese patients had received prescriptions of the 36 drugs that are affected by actionable pharmacogenetics variants in 2019, accounting for one-seventh of the local Chinese population. The research team estimated that 23.1% of the patients receiving the prescribed drugs have actionable pharmacogenetic phenotypes, which should have prescription adjustment according to the international clinical guidelines. Drugs with greatest pharmacogenetic impact include simvastatin (lipid-lowering drug), clopidogrel (antiplatelet drug), and ibuprofen (one of the non-steroidal anti-inflammatory drugs). However, as the research findings showed, there are a substantial number of scarcely documented pharmacogenetic variants commonly found among Hong Kong Chinese patients. This indicates the potential to further develop personalised pharmacogenetic guidelines of medical prescription in Hong Kong to achieve higher drug efficacy with minimised risk of adverse drug reactions.About the research teamThis research was led by Dr Brian Chung Hon-yin, Clinical Associate Professor, Department of Paediatrics and Adolescent Medicine, HKUMed; Dr Clara Tang Sze-man, Assistant Professor, Department of Surgery, HKUMed and Dr Yeung Kit-san, Postdoctoral Fellow, Department of Paediatrics and Adolescent Medicine, HKUMed. Mr Mullin Yu Ho-chung, PhD candidate from Department of Paediatrics and Adolescent Medicine, HKUMed, and Mr Marcus Chan Chun-yin, MBBS Year 6 student, from Department of Paediatrics and Adolescent Medicine, HKUMed are the first authors. Other contributors include: Professor Godfrey Chan Chi-fung, Professor Lau Yu-lung, Dr Lee So-lun, Dr Yang Wanling, Ms Claudia Chung Ching-yan, Dr Christopher Mak Chun-yu, Mr Jeffrey Chau Fong-ting, Ms Mianne Lee, Ms Jasmine Fung Lee-fong, Ms Mandy Tsang Ho-yin, Dr Joshua Chan Chun-ki, Dr Yang Jing and Dr Wilfred Wong Hing-sang from Department of Paediatrics and Adolescent Medicine, HKUMed; Professor Paul Tam Kwong-hang and Dr Patrick Chung Ho-yu from Department of Surgery, HKUMed; Mr William Chui Chun-ming, Mr Andrew Li Wang-tat and Ms Chara Yip Yin-wa from Department of Pharmacy, Queen Mary Hospital.This study was supported by the Society for the Relief of Disabled Children, the Health and Medical Research Fund of the Food and Health Bureau, Government of the Hong Kong Special Administrative Region; Li Ka Shing Faculty of Medicine – Enhanced New Staff Start-up Research, the Children’s Heart Foundation, and Mr and Mrs Edward CM Wong Foundation. /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:adolescent, anti-inflammatory, chinese, data analysis, Government, health, heart foundation, Hong Kong, Medical research, metabolism, paediatrics, public health, Queen, statistics, United States, university, University of Hong Konglast_img read more

Northern Class 331s to serve Leeds from May

first_imgUK: Regional franchisee Northern expects to put its first CAF-built Class 331 EMUs into passenger services between Leeds and Doncaster with the May 19 timetable change, having received regulatory authorisation from the Office of Road & Rail.The approval applies to the 31 three-car sets and the 12 four-car versions. Northern says it is working to begin driver and guard training as soon as possible, ahead of a gradual introduction into passenger service.As part of the authorisation, ORR has issued a requirement on February 22 for Arriva Trains Northern to demonstrate ‘before the trains are put into passenger service, the arrangements for controlling the Platform-Train Interface risks’ at ‘all stations where the Class 331s will operate’. This covers both stepping distances between train and platform and the use of automatic selective door operation at short platforms.There are currently large variations in stepping distances across the UK network, and ORR was reportedly minded to require train operators to resolve the problem. However, the operators responded that Network Rail was responsible for the differing platform heights, arguing that any work to create a more uniform PTI should be delivered and funded by the infrastructure manager.Industry sources point out that modifying hundreds of platforms would cost millions, if not billions of pounds and NR is currently not funded for this work, however desirable it might be.Northern has awarded CAF a contract to install its LeadMind remote monitoring and real-time analytics system to support the condition-based maintenance of all 101 Civity EMUs and DMUs of Classes 331 and 195. The equipment will also be fitted to the legacy fleet of Class 170 and 158 DMUs, bringing the total to 431 vehicles.last_img read more

Sky Bet Championship preview

first_imgIt was a blockbuster weekend to kick-off the Sky Bet Championship season with a total of 43 goals being scored – a record-breaking start to the new campaign.The Rams battled the Royals to get it all underway on Friday night, and it was Frank Lampard’s Derby who wrapped up the points in his first competitive game in senior management.Derby have continued to improve in the transfer market, with Martyn Waghorn the latest recruit having scored 16 for Ipswich last season.The TV cameras will be watching Derby once again on Saturday evening, as they welcome Marcelo Bielsa’s Leeds to Pride Park.The Whites had the perfect start to the season with a 3-1 victory over 9/2 title-favourites Stoke City, and their Argentine boss galvanised a team who ended in mid-table in May, much to the delight of the packed Elland Road crowd.These two teams have strength in attack, setting up what promises to be an entertaining match-up to conclude the weekend’s action.Gary Rowett’s Stoke will look to bounce back when they host Brentford on Saturday. It’ll be no easy contest, with the Bees hammering Rotherham 5-1 to top the table at this very early stage.Despite losing John Egan, Florian Jozefzoon and Konstantin Kerschbaumer this summer, Brentford once again look like play-off contenders and Dean Smith will have full confidence that his side are capable of victory.Wigan, recently promoted back to the second-tier, started off the season on the right side of a five-goal thriller against Sheffield Wednesday – and they come up against Aston Villa who got past Hull on Monday night.It was a summer of uncertainty at Villa Park but the club look in the right place to potentially improve on last season’s defeat in the play-off final.They both drew 2-2 on opening weekend, and Blackburn host Millwall with both optimistic they can pick up three points.Millwall’s wonderful 2017/18 campaign saw them narrowly miss out on the play-offs, while Blackburn bounced back following an exciting title race with Wigan in League One.Bolton, fresh from victory over West Brom, host Bristol City – although EFL title sponsors Sky Bet fancy Bristol City at 7/5 despite a draw with Nottingham Forest last weekend.Elsewhere, Middlesbrough’s start has seen them come from behind to draw 2-2 at Millwall and then blow away Sheffield United with three first-half goals in midweek – they welcome a Birmingham side who were held by Norwich.Daniel Farke’s Canaries will aim for their first victory when they take on West Brom – the Baggies are buoyed by a point away at Forest, with Matt Phillips’ wonderful technique on the half-volley earning a 1-1 draw.Forest themselves will return to the City Ground with hope of their first victory as they take on Paul Clement’s Reading – who put in a good first-half showing against Derby on Friday night despite defeat.Steve McClaren gets his first competitive taste at Loftus Road when QPR welcome Sheffield United – both are aiming for their first points of the campaign.Rotherham host an Ipswich side who brought in two impressive performers in League One last year – Jon Nolan and Toto Nsiala – whilst an all-Yorkshire affair at Hillsborough sees Sheffield Wednesday meet Hull City.Swansea, who came from behind at Bramall Lane to down the Blades, face off against Preston who were also victorious in front of their home fans last time out.Sporting Life has teamed up with Sky Bet to bring readers an exclusive price boosted accumulator from this weekend’s EFL action. You can back Ipswich, Portsmouth and Notts County all to win enhanced to 20/1 with Sky Bet by heading here.last_img read more

Lawrence County Inmate Roster – 7.19.17

first_imgArrest Report for Courts07/17/2017 thru 07/19/2017Book Date Time DOB SSN Charge Charge Sex Arr Ag Bail Bail AgencyCause No. Code(s) Description(s)____________________________________________________________________________________________________________________________________07/17/2017 1031 10/30/1966 *********** M LCPD 0.00 CIRCRT HOLD LAAWBREY,JAMES A 47C01-1002-JP-62 00000000180 RETURNED FOR COURT Court: CIRCUIT COURT Date/Time: -0000Citizen? Yes Birth Place Country: US City: MORGAN CO State: INClass: CIVILRelease Date/Time: 07/18/2017-1115____________________________________________________________________________________________________________________________________ 07/17/2017 1354 09/29/1995 *********** M LCPD 5,000.00JOHNSON,WILLIAM M JR BATTERY/DOM BATTERY/DOMESTIC Court: Date/Time: -0000Citizen? Yes Birth Place Country: US City: LAWRENCE COUNTY State: INClass:____________________________________________________________________________________________________________________________________07/17/2017 2223 03/22/1990 *********** M BEDFORD PD 0.00POWERS,LORDMEISTER S ON-SITE 00000000182 POSSESSION OF METHAM Court: Date/Time: -0000ON-SITE 00000000109 POSS SCHED III Court: Date/Time: -0000ON-SITE 00000000148 RESISTING LAW ENFORC Court: Date/Time: -0000ON-SITE 00000000130 VISITING COMMON NUIS Court: Date/Time: -0000Citizen? Yes Birth Place Country: US City: LAWRENCE CO State: INClass:____________________________________________________________________________________________________________________________________07/18/2017 0927 05/30/1994 *********** M BEDFORD PD 0.00BRUHY,ZACHERY E 47D02-1506-F3-624 00000000203 PETITION TO MODIFY Court: Date/Time: -0000Citizen? Yes Birth Place Country: US City: FLORIDA State: FLClass: FELONY____________________________________________________________________________________________________________________________________07/18/2017 1313 12/11/1981 *********** F LCPD 20,000.00DECKARD,SARAH H ON-SITE 00000000184 DEALING METHAMPHETAM Court: SUPERIOR COURT II Date/Time: -0000ON-SITE 00000000153 POSSESSION OF A SYRI Court: SUPERIOR COURT II Date/Time: -0000Citizen? Yes Birth Place Country: US City: BLOOMINGTON State: INClass: FELONY____________________________________________________________________________________________________________________________________07/18/2017 1355 08/03/1979 *********** M BEDFORD PD 0.00MCBRIDE,JOSHUA L 47D01-1605-CM-570 00000000187 ADDITIONAL CRIMINAL Court: SUPERIOR COURT I Date/Time: -0000Citizen? Yes Birth Place Country: US City: OHIO State: OHClass: MISDEMEANOR____________________________________________________________________________________________________________________________________07/18/2017 1721 06/01/1963 *********** M LCPD 50,000.00CAPPS,HERMAN A JR ON-SITE 00000000184 DEALING METHAMPHETAM Court: SUPERIOR COURT II Date/Time: -0000ON-SITE 00000000182 POSSESSION OF METHAM Court: SUPERIOR COURT II Date/Time: -0000ON-SITE 00000000129 MAINTAINING COMMON N Court: SUPERIOR COURT II Date/Time: -0000ON-SITE 00000000118 POSS MARIJUANA U/30 Court: SUPERIOR COURT II Date/Time: -0000Run: 19-JUL-2017 8:54 LAWRENCE COUNTY Page: 2JBS15 – Run By: FODDRILL,KYLEAGENCY: 00 J A I L M A N A G E M E N TArrest Report for Courts07/17/2017 thru 07/19/2017Book Date Time DOB SSN Charge Charge Sex Arr Ag Bail Bail AgencyCause No. Code(s) Description(s)____________________________________________________________________________________________________________________________________Citizen? Yes Birth Place Country: US City: LAWRENCE CO State: INClass: FELONY____________________________________________________________________________________________________________________________________07/19/2017 0020 12/19/1992 *********** M LCPD 0.00DECKARD,RICHARD S 47-D02-1402-CM-19 00000000203 PETITION TO MODIFY Court: Date/Time: -0000Citizen? Yes Birth Place Country: City: BLOOMINGTON State: INClass: MISDEMEANOR____________________________________________________________________________________________________________________________________07/19/2017 0130 05/13/1992 *********** M MITCHELL P 0.00HOPPER,STEVEN P 47D021611F61386 00000000201 PETITION TO REVOKE Court: Date/Time: -0000Citizen? Yes Birth Place Country: US City: LAWRENCE State: INClass: FELONYlast_img read more

SXSW: Sunday Keynote – Open Source Hardware

first_imgWhy Tech Companies Need Simpler Terms of Servic… sean ammirati 8 Best WordPress Hosting Solutions on the Market Related Posts Sean Ammirati of mSpoke is at SXSW in Austin, TX (USA). He is reportingfor Read/WriteWeb throughout the event. Today’s keynote was aconversation between Limor Fried of AdafruitIndustries and Phillip Torrone, the senior editor of MAKE magazine. In the conversation, they discussed anew movement called ‘Open Source Hardware’.Definition of Open Source HardwareOpen Source Hardware involves releasing all of the information necessary, to allowindividuals to acquire the individual components of a device and understand how toassemble them together into a functioning device. Also, many individuals end up thenextending a device to incorporate entirely new and novel uses. Limor talked aboutmultiple types of open source hardware – including releasing the following:mechanics in an open interface markup file under creative commons;circuit level design in an open format released under creative commons;firmware source code (more like traditional open source licenses);data sheets and parts lists including where to find the parts (it isincreasingly becoming hard to find each of the individual parts);finally there is the firmware and APIs, again under a more traditional opensource license.ExamplesLimor and Fried reviewed a number of examples, including:The LinkSys WRT54G Line of Routers– provided the ability to upgrade the $75 router’s firmware to make it significantly morevaluable;Roomba – Provided access to the Hardware API, so that you can integrate additionalhardware into the robotics platform. This was so successful, that iRobot just released anEducational Bot which is the Roomba without the vacuum.Business ModelI found each of the above examples interesting, because they are ‘for profit’companies leveraging ‘Open Source Hardware’ projects. Just like for profit businesseshave leveraged Open Source Software.Interestingly, Fried’s own company Adafruit Industries actually provides kits with allof the components necessary to complete the electronics they develop and release, undercreative commons with attribution license. According to Limor, this has actually become aprofitable business; because people are interested in building these electronics, butthey don’t want to do the work to track down each component, and are willing to pay apremium to get all of the components from one source.ConclusionThere was a lot of discussion today about the advent of “prosumers” in mediaand specifically web media. Today’s presentation was very interesting to see how thissame trend is being applied to another aspect of technology. I was actually tempted tocall this post “Read/Write Electronics” 🙂center_img Top Reasons to Go With Managed WordPress Hosting Tags:#conferences#SXSW 2007#web A Web Developer’s New Best Friend is the AI Wai…last_img read more

Strong Password rules for ME

first_img-jeff What are the rules for creating ME passwords? I can’t tell you how many times I’ve been asked this, and I’m sure I’m not the only one. In reality we’ve documented these rules in explicit detail in the Network Interface Guide of the AMT SDK . However that’s not something a general end-user is typically going to want to read.Gael Holmes has recently blogged about these rules. If you’re at all interested, check out her post .last_img

Sachin Tendulkar falls six short of long-awaited 100th century

first_imgUnlike on the last three mornings of the Test match, on Friday there was unusually hectic activity on the Marine Drive, connecting the ‘D’ Road on which the Wankhede Stadium is located, barely 15 metres away from the junction.People looked anxious, even worried, as they looked around for tickets to get inside the venue with the hope to watch Sachin Tendulkar complete his 100th international century and make history.”Us gali mein jaao, sab milega (go to that lane, you’ll get everything),” a person was seen telling another person who was looking for tickets, just outside the main stadium gate. Officials claimed that all tickets for the fourth day of the third Test against the West Indies were sold out, but tickets were reportedly being sold in black.Just a little farther from the Wankhede, on the PM Shukla Marg-Marine Drive junction, MMK College (Bandra) students had put up a special billboard, calling for a ‘signature campaign’ for Tendulkar.The impromptu billboard had two giant photos of Sachin Ramesh Tendulkar (SRT) and the words ‘Young India Salutes You SRT’ on it.Millions of his fans around the world would have tuned in to either their television/radio sets or online streaming to be ‘part’ of the history that seemed imminent – Tendulkar required 33 more runs to become the first ever batsman to score the magical feat.Those who came late ran to their seats, eager that they don’t miss Tendulkar scoring the magic 100th run. But all of them were shocked to watch the maestro, at 94, slash at a rising ball from speedster Ravi Rampaul into the safe hands of captain Darren Sammy at the second slip. Suddenly, the packed and noisy stadium fell silent. All the anticipation and expectations came to nought as the maestro began the slow and long walk back to the dressing room.advertisementIt took some time for the spectators to accept the reality – that Tendulkar had indeed failed to get to his 52nd Test century; he has 48 tons in ODIs. He has now gone 16 innings, or eight months and 13 days – in both Tests and ODIs – without a century, though he had come close to it on a few occasions after scoring his 99th ton, against South Africa during the World Cup on March 12.And when normalcy returned to the Wankhede Stadium, people were quick to pronounce a variety of reasons as to why the 38-year-old righthanded batsman failed to score six more runs.While some felt he was too anxious to get to the mark, others insisted that he had become habitual of playing the uppish shot over the slips due to excess ODI cricket.There were others who said that Tendulkar would like to score the much-anticipated century of his 22-year international career in the five-match One-day International series against the Caribbean team, starting on November 29 in Cuttack. As it turned out, Tendulkar has been rested for the first three ODIs.last_img read more

PM to inaugurate Mary Koms academy in presence of Vijender, Sushil

first_imgNew Delhi, Mar 12 (PTI) Prime Minister Narendra Modi will inaugurate the Mary Kom Regional Boxing Foundation in Imphal on March 16 and present in the long-awaited event will be Olympic medallists — boxer Vijender Kumar and wrestler Sushil Kumar. Nestled at the foot of Langol hills in Manipurs Imphal West district, Mary Koms Boxing Academy, spread across 3.3 acres, is around 10 km from the center of state capital Imphal. It currently houses 45 young boxers, including 20 girls, at the three-storey building. The land was allotted by the Manipur government in 2013, and the academys construction was funded by National Sports Development Fund (NSDF). “The foundation is grateful to both central and state government for establishment of these sports facilities after many years of struggle since its inception in 2006,” it said in a press release.”The foundation expresses their gratitude to PMO for making (it) to the event and formally handover the buildings to the foundation for promotion of boxing sports.” A five-time world and Asian champion, Mary Kom is also the countrys only woman boxer with an Olympic medal (a bronze won in London 2012 Games). The 35-year-old was christened Magnificent Mary by the International Boxing Association (AIBA) a few years ago for her stellar career, which also includes an Asian Games gold medal. The most recent chapter of her extraordinary life journey was becoming a Rajya Sabha MP in 2016 and winning her fifth Asian Championships gold medal a year later. PTI AH AHlast_img read more